What is β-Caryophyllene?

β-Caryophyllene (Beta-Caryophyllene)

Overview

β-Caryophyllene is a spicy, woody terpene with notes of black pepper, cloves, and warm spice. It is unique among terpenes because it directly interacts with the endocannabinoid system, specifically activating CB2 receptors. Naturally found in black pepper, clove, basil, oregano, and cinnamon, it bridges the gap between terpenes and cannabinoids in its mode of action.

Best Suited For

• Pain relief and inflammation control

• Recovery after physical exertion

• Balancing high-THC profiles

• Reducing anxiety and irritability

• Daytime use in chronic or inflammatory conditions

Effects

• Anti-inflammatory and analgesic effects

• Pain reduction without psychoactivity

• Gentle physical relaxation

• Modulation of overactive immune and stress responses

• Supports homeostasis and immune balance

Mechanism of Action

• Activates CB2 receptors, unlike most terpenes

• Regulates inflammatory and immune pathways

• Does not bind to CB1, thus non-psychoactive

• Enhances antioxidant defense and cellular protection

Therapeutic Research Focus

• Chronic inflammation

• Arthritis and muscle pain

• Gastrointestinal conditions (including IBS)

• Neuropathic pain

• Anxiety and hyperexcitability disorders

OG Lab Strains Containing β-Caryophyllene

• Runtz

• Banana Hammock RBX1

• Super Boof

• Grandmaster Sexy

Synergy (Entourage Effect)

• Caryophyllene + Myrcene — Enhanced analgesia and physical comfort

• Caryophyllene + Linalool — Anxiolytic synergy without sedation

• Caryophyllene + CBD — Anti-inflammatory balance without intoxication

β-Caryophyllene acts as a bridge molecule — grounding, balancing, and healing without altering perception.