What is CBDV?
Explore CBDV's role in neurological regulation and its unique synergy with other cannabinoids.
TL;DR | Quick Summary
CBDV (Cannabidivarin)
Overview
Cannabidivarin (CBDV) is a non-psychoactive cannabinoid, structurally similar to CBD but distinguished by a shorter side chain — reflected in the suffix “varin.” This structural difference alters its receptor interactions and makes CBDV particularly relevant to neurological and sensorimotor regulation.
CBDV does not directly activate CB1 or CB2 receptors, but acts through:
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TRPV1, TRPA1, TRPM8 channels
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GABA receptors
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and possible modulation of SCN sodium channels associated with seizure activity
Effects
Psychological
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Does not induce euphoria or alter perception
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May reduce hypersensitivity (both sensory and emotional)
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Supports neuro-emotional regulation in highly sensitive individuals
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[Unverified] Shows promise in studies related to ADHD, autism spectrum conditions, and PTSD
Physiological
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Demonstrates strong anticonvulsant activity in experimental models
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Reduces involuntary tics and neuromuscular tension
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Suppresses inflammatory markers
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[Unverified] Investigated for potential benefit in gastrointestinal disorders, including Crohn’s disease
Occurrence
CBDV is rarely found in natural cannabis strains and is typically present in specialized varin-type cultivars. Its concentration is usually below 1%, though selective breeding can increase it significantly — e.g., Strain Hunter’s Malawi Gold (varin selection). Not currently included in OG Lab genetics, but available as an isolate or in medical-grade extracts.
Synergy
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CBDV + CBD — Soft regulation of neural hyperreactivity
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CBDV + CBG — Enhances nervous system stability and tone
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CBDV + Caryophyllene — Anti-inflammatory synergy without sedation
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CBDV + CBN — Deep physical calm for sensory overload
CBDV doesn’t produce a sensation — it acts as a quiet regulator of neural imbalance.
Pharmacological Properties
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One of the most promising cannabinoids for neurological modulation
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Differs from CBD by acting faster and more motor-focused
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Non-tolerant: does not induce adaptation with prolonged use
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Suitable for sensitive individuals, anxiety-prone adults, and pediatric therapeutic settings
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Compatible with microdosing for background stabilization
Summary
CBDV is a neural recalibrator without an effect. It isn’t for pleasure or feeling — it helps the brain and body stop firing noise into the system.
CBDV is not enhancement — it’s a return to baseline, where the nervous system no longer treats the world as a threat.
Quick Answer
CBDV, or Cannabidivarin, is a non-psychoactive cannabinoid that supports neurological regulation through unique receptor interactions.