What is Humulene?

Humulene (α-Humulene)

Overview

Humulene — also known as α-humulene — is a woody, hoppy, and slightly spicy terpene commonly found in cannabis. It is naturally present in hops, basil, clove, sage, and black pepper. Humulene is distinguished by its anti-inflammatory and appetite-suppressing (anorexigenic) properties, contributing to balanced, clear-headed terpene profiles.

Best Suited For

• Reducing inflammation and swelling

• Supporting appetite control and mindful eating

• Post-exercise recovery

• Strains associated with clarity and non-sedative balance

• Maintaining daytime focus without overstimulation

Effects

• Anti-inflammatory activity through cytokine regulation

• Appetite suppression and reduced food cravings

• Light mental stimulation without anxiety

• Balances THC-rich profiles by softening intensity

• Exhibits mild antibacterial and protective effects

Mechanism of Action

• Suppresses production of pro-inflammatory cytokines

• Modulates TRP channels involved in pain and temperature regulation

• Influences neuropeptides that control appetite and metabolism

• Acts as an antagonist of NF-κB inflammatory pathways

Therapeutic Research Focus

• Chronic and intestinal inflammation

• Appetite regulation and prevention of overeating

• Support in metabolic and weight-related disorders

• Adjunctive therapy for chronic pain

OG Lab Strains Containing Humulene

• Blueberry Bang Bang

• Pink Bubble Gum

• Runtz

Synergy (Entourage Effect)

• Humulene + β-Caryophyllene — Strong anti-inflammatory and restorative duo

• Humulene + Myrcene — Pain relief and recovery without sedation

• Humulene + Limonene — Energy and focus with appetite regulation

Humulene is the quiet regulator — promoting clarity, balance, and control without overstimulation or heaviness.